PaCO2 in group A was (35.5 ± 2.7), (40.7 ± 3.5) mmHg in T1 and T2 respectively, which was significantly lower than that in group B (39.9 ± 3.1), (49.4 ± 4.7) mmHg (P & lt; 0.05), while VM was (68.9 ± 8.1) cm / s in T3, which was significantly lower than that in group B (87.9 ± 9.6) cm / S (P & lt; 0.05).
Objective To observe the effect of positive end expiratory pressure ventilation on cerebral hemodynamics in patients undergoing laparoscopic radical gastrectomy under general anesthesia.
Ventilation parameters in group A: tidal volume (VT) 8ml / kg, respiratory rate (RR) 12 times / min, positive end expiratory pressure (PEEP) 5cmh2o (1cmh2o = 0.098kpa).
Results the expression rate of EphA2 in gastric cancer was significantly higher than that in adjacent tissues (86.59% vs 20.73%, P & lt; 0.01), and the expression rate of CD133 in gastric cancer was significantly higher than that in adjacent tissues (67.07% vs 10.98%, P & lt; 0.01); The expression level of EphA2 was significantly correlated with TNM stage and lymph node metastasis of gastric cancer (P & lt; 0.05), and the expression level of CD133 was significantly correlated with histological differentiation, TNM stage and lymph node metastasis of gastric cancer (P & lt; 0.05).
Compared with that before pneumoperitoneum, Da jvo2 decreased significantly in the two groups 2 hours after pneumoperitoneum (P & lt; 0.05).
Conclusion the overexpression of EphA2 and CD133 may play a role in the occurrence and development of gastric cancer.
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Combined with the follow-up data, the relationship between the number and distribution of Tregs infiltration in gastric cancer and the prognosis of patients was analyzed.
However, the rising trend of VM, SjvO2 and PaCO2 in group A was more mild than that in group B.
Methods the expression levels of EphA2 and CD133 in cancer tissues and adjacent tissues of 82 patients with gastric cancer were detected by immunohistochemistry.
Conclusion low level positive end expiratory pressure ventilation can effectively reduce intraoperative hypercapnia and maintain the stability of cerebral hemodynamics in patients undergoing laparoscopic radical gastrectomy under general anesthesia, so as to improve the state of cerebral hyperperfusion and the balance of cerebral blood flow and cerebral oxygen supply and demand..
Results the number of invasive Tregs in cancer tissues [(7.36 ± 8.06) was significantly higher than that in adjacent mucosa [(2.10 ± 2.97), P & lt; 0.01], and the number of invasive Tregs in cancer stroma [(8.01 ± 10.01) was significantly higher than that in cancer nests [(0.47 ± 1.49), P & lt; 0.01]; There was no significant correlation between invasive Tregs and overall survival time (OS) (P & gt; 0.05); Tregs was positively correlated with OS (P & lt; 0.01).
The radial artery blood and internal jugular vein bulb blood at each time point were taken for blood gas analysis, and the arterial partial oxygen pressure (PaO2) and Arterial partial pressure of carbon dioxide (PaCO2), arterial oxygen saturation (SaO2) and hemoglobin (HB); Internal jugular vein oxygen partial pressure (pjvo2) and internal jugular vein oxygen saturation (SjvO2), and the cerebral artery and internal jugular vein oxygen content (cjvo2) and their difference (DA jvo2) were calculated according to Fick formula.
Results compared with that before pneumoperitoneum, VM, SjvO2 and PaCO2 in the two groups increased significantly at each time point after pneumoperitoneum (P & lt; 0.05).
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Ventilation parameters in group B: vt8ml / kg, rr12 times / min.
Detecting the level of Tregs infiltration in cancer nest is helpful to judge the good prognosis of gastric cancer.
Methods immunohistochemical streptavidin peroxidase (SP) method was used to detect the expression of forkhead like transcription factor 3 (Foxp3) in 106 cases of gastric adenocarcinoma.
Compared between groups, the decrease range of group A was significantly greater than that of group B (P & lt; 0.05).
Methods 80 patients undergoing laparoscopic radical gastrectomy under general anesthesia were randomly divided into group A and group B, with 40 cases in each group.
Conclusion there is Tregs infiltration in gastric cancer and its distribution is different.
The changes of mean blood flow velocity (VM), mean arterial pressure (map), heart rate (HR), transcutaneous oxygen saturation (SpO2) and end expiratory carbon dioxide partial pressure (PetCO2) of middle cerebral artery were recorded before pneumoperitoneum (T0), 30min (T1), 1H (T2) and 2H (T3).
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Objective to investigate the expression of Eph receptor tyrosine kinase A2 (EphA2) and CD133 in gastric cancer and their relationship with clinicopathological features and prognosis.
Objective to investigate the relationship between regulatory T cells (Tregs) infiltration and its distribution and prognosis in patients with gastric adenocarcinoma.